For a full list of publications, please visit pubmed site
Review articles are in pink; lab member names are in bold
Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression.
Kalfakakou D, Cameron DC, Kawaler EA, Tsuda M, Wang L, Jing X, Hajdu C, Tamayo DL, Shim Y, Ackermann A, Weissinger D, Zimny H, Hernandez R, Beier M, Dimartino D, Meyn P, Rice K, Selvaraj S, Loomis C, Heguy A, Lund AW, Sears RC, Welling TH, Dolgalev I, Tsirigos A, Simeone DM.
bioRxiv [Preprint]. 2025 Feb 15:2025.02.11.637729. doi: 10.1101/2025.02.11.637729.
Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta2
Serena Lucotti∙ Yusuke Ogitani ∙ Candia M. Kenific ∙ Jacob Geri ∙ Young Hun Kim ∙ Jinghua Gu ∙ Uthra Balaji ∙ Linda Bojmar ∙ Lee Shaashua ∙ Yi Song ∙ Michele Cioffi ∙ Pernille Lauritzen ∙ Oveen M. Joseph ∙ Tetsuhiko Asao ∙ Paul M. Grandgenett ∙ Michael A. Hollingsworth ∙ Christopher Peralta ∙ Alexandra E. Pagano ∙ Henrik Molina ∙ Harry B. Lengel ∙ Elizabeth G. Dunne ∙ Xiaohong Jing ∙ Madeleine Schmitter ∙ Lucia Borriello ∙ Thomas Miller ∙ Haiying Zhang ∙ Yevgeniy Romin ∙ Katia Manova ∙ Doru Paul ∙ H. Lawrence Remmel ∙ Eileen M. O’Reilly ∙ William R. Jarnagin ∙ David Kelsen ∙ Sharon M. Castellino ∙ Lisa Giulino-Roth ∙ David R. Jones ∙ John S. Condeelis ∙ Virginia Pascual ∙ James B. Bussel ∙ Nancy Boudreau ∙ Irina Matei ∙ David Entenberg ∙ Jacqueline F. Bromberg ∙ Diane M. Simeone ∙ David Lydend
Cell. 2025, 188, 1-20 [https://pubmed.ncbi.nlm.nih.gov/39938515/]
The Pancreatic Cancer Early Detection (PRECEDE) Study is a Global Effort to Drive Early Detection: Baseline Imaging Findings in High-Risk Individuals.
Zogopoulos G, Haimi I, Sanoba SA, Everett JN, Wang Y, Katona BW, Farrell JJ, Grossberg AJ, Paiella S, Klute KA, Bi Y, Wallace MB, Kwon RS, Stoffel EM, Wadlow RC, Sussman DA, Merchant NB, Permuth JB, Golan T, Raitses-Gurevich M, Lowy AM, Liau J, Jeter JM, Lindberg JM, Chung DC, Earl J, Brentnall TA, Schrader KA, Kaul V, Huang C, Chandarana H, Smerdon C, Graff JJ, Kastrinos F, Kupfer SS, Lucas AL, Sears RC, Brand RE, Parmigiani G, Simeone DM; PRECEDE Consortium.
J Natl Compr Canc Netw. 2024 Apr;22(3):158-166. doi: 10.6004/jnccn.2023.7097.
Are All Cysts Created Equal?: Pancreatic Cystic Neoplasms in Patients with Familial or Genetic Risk Factors for Pancreatic Cancer.
Haimi I, Sanoba S, Everett J, Simeone DM.
Gastrointest Endosc Clin N Am. 2023 Jul;33(3):547-557. doi: 10.1016/j.giec.2023.03.002
POLQ inhibition elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma via cGAS/STING signaling
Grace Oh, Annie Wang, Lidong Wang, Jiufeng Li, Gregor Werba, Daniel Weissinger, Ende Zhao, Surajit Dhara, Rosmel E Hernandez, Amanda Ackermann, Sarina Porcella, Despoina Kalfakakou, Igor Dolgalev, Emily Kawaler, Talia Golan, Theodore H Welling, Agnel Sfeir, Diane M Simeone
J Clin Invest. 2023;133(11):e165934 [https://pubmed.ncbi.nlm.nih.gov/36976649/]
Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment
Werba G, Weissinger D, Kawaler EA, Zhao E, Kalfakakou D, Dhara S, Wang L, Lim HB, Oh G, Jing X, Beri N, Khanna L, Gonda T, Oberstein P, Hajdu C, Loomis C, Heguy A, Sherman MH, Lund AW, Welling TH, Dolgalev I, Tsirigos A, Simeone DM.
Nat Commun. 2023 Feb 13;14(1):797. doi: 10.1038/s41467-023-36296-4. PMID: 36781852
ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis.
Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, Simeone DM.
Genes Dev. 2019 Jun 1;33(11-12):641-655. doi: 10.1101/gad.323303.118. PMID: 31048544
Advancing Clinical Trial Innovation in Pancreatic Cancer: A Conversation Between Diane Simeone, Ken Herrmann, and Johannes Czernin.
Simeone DM, Herrmann K, Czernin J.
J Nucl Med. 2023 Feb;64(2):185-187. doi: 10.2967/jnumed.123.265432.
Impact of comprehensive family history and genetic analysis in the multidisciplinary pancreatic tumor clinic setting.
Everett JN, Sanoba SA, Jing X, Stender C, Schmitter M, Baptiste A, Chun J, Kawaler EA, Khanna LG, Gross SA, Gonda TA, Beri N, Oberstein PE, Simeone DM.
Cancer Med. 2023 Feb;12(3):2345-2355. doi: 10.1002/cam4.5059.
Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment.
Wood LD, Canto MI, Jaffee EM, Simeone DM.
Gastroenterology. 2022 Aug;163(2):386-402.e1. doi: 10.1053/j.gastro.2022.03.056.
The biological underpinnings of therapeutic resistance in pancreatic cancer.
Beatty GL, Werba G, Lyssiotis CA, Simeone DM.
Genes Dev. 2021 Jul 1;35(13-14):940-962. doi: 10.1101/gad.348523.121.
Cancer surveillance awareness and practice among families at increased risk for pancreatic adenocarcinoma.
Everett JN, Burgos G, Chun J, Baptiste A, Khanna LG, Oberstein PE, Simeone DM.
Cancer. 2021 Jul 1;127(13):2271-2278. doi: 10.1002/cncr.33500.
ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer.
Purohit V, Wang L, Yang H, Li J, Ney GM, Gumkowski ER, Vaidya AJ, Wang A, Bhardwaj A, Zhao E, Dolgalev I, Zamperone A, Abel EV, Magliano MPD, Crawford HC, Diolaiti D, Papagiannakopoulos TY, Lyssiotis CA, Simeone DM.
Genes Dev. 2021 Feb 1;35(3-4):218-233. doi: 10.1101/gad.344184.120